Coenzyme Q10 (CoQ10) is a nutrient or coenzyme found in the cells of the body. It plays the vital role of supporting cellular, assisting organs to perform at their best and help to protect cells and blood lipid from oxidation.
There are two forms of CoQ10:
1. Ubiquinone – the inactive form
2. Ubiquinol – the active form
Ubiquinol is the major form of CoQ10 that naturally occurs in the body – more than 95% of the total CoQ10 in plasma in a young, healthy body is in the Ubiquinol form.
CoQ10 and aging
The concentration of CoQ10 in the body may decrease year by year, indicating that it has a close relationship with aging.
CoQ10 also starts to decline rapidly when you are over 40 years old, poor diet, exposure to free radical and certain medication like cholesterol-lowering medication.
But studies also show that at around 30 years old, coq10 levels in the body may begin to decrease.
This is expected due to current lifestyle and not enough good nutrient from diet.
Older individuals may have decreased CoQ10 levels, as well as impaired ability to efficiently convert Ubiquinone to Ubiquinol due to:
- increased metabolic demand
- oxidative stress
- insufficient CoQ10 intake
- gene mutation
- statin (cholesterol lowering drug) intake
Ubiquinol is a powerful antioxidant, which occurs naturally in the body, as well as some foods.
Ubiquinone must be converted to ubiquinol before body can utilise it.
Ubiquinol or Ubiquinone?
Ubiquinol = “ready-to-use” CoQ10
- ubiquinol is the active antioxidant form that is responsible for the benefits associated with CoQ10
- ubiquinol has superior availability t ordinary ubiquinone
- ubiquinol is 3-8 times more absorbable than ubiquinone
- 18 clinical studies focusing on ubiquinol and its benefits highlight the superior efficacy
So, the only CoQ10 supplements that you must take is ubiquinol not ubiquinone.
Ubiquinol for energy support
CoQ10 promotes energy production in mitochondria.
A study in 2013 demonstrated enhanced physical performance with six weeks of daily supplementation of 300mg ubiquinol, as measured by maximum power output.
The effect of ubiquinol supplementation enhanced peak power production in comparison to placebo.
It is also beneficial for patients taking statin medications with reported myopathy side effects.
in a 2012 study, researchers examined the effects of Ubiquinol in patients with statin myopathy.
After 6 months of supplementing with 60 mg Ubiquinol per day, there was a decline in muscle pain by 54% and reduced muscle weakness by 44%.
Benefits of CoQ10
- Strong antioxidant – helps soak up oxidative stress and free radicals
- Support the heart – helps maintain a healthy heart and vascular system
- Cholesterol support – helps maintain healthy LDL cholesterol levels in healthy people
- More easily absorbed into the body compared to standard CoQ10 (ubiquinone)
- Powers your cells – helps your body’s cells convert energy
- Improve heart health especially for heart failure patient
CoQ10 also strengthens heart muscle, boost its capacity to pump blood throughout the body to nourish tissues, while reducing risk of atrial fibrillation.
CoQ10 deficiency deprives the heart of a critical factor in its energy supple, and can be a key contributor to the impaired pumping function we identify as heart failure.
This is because mitochondria in the heart (and everywhere else in the body) rely on CoQ10 for energy production. Many research has shown that supplementing heart failure patient with CoQ10 improve the symptoms and reduces major adverse cardiovascular events.
Proper supplementation with CoQ10 has been shown to improve functional parameters of heart failure, reduce complications such as heart arrhythmias, and produce no significant side effects,
Recommended dosage for normal and healthy people is 100mg – 300mg of ubiquinol and 400mg and above for heart failure patients.
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