Triglycerides interact with LDL cholesterol to form a particularly dangerous sub-type of LDL known as small-dense LDL. Small-dense LDL particles penetrate the endothelial layer and contribute to plaque formation much more efficiently than larger, more buoyant LDL particles. Fasting triglycerides should be kept below 80 mg/dL to limit the formation of small-dense LDL particles.
In 1992 there was a study on blood of centenarians to find any commonalities. The finding were, there are only three commonalities: LOW TRIGLYCERIDES, high HDL cholesterol, low fasting insulin.
A study by Harvard University, published in Journal “Circulation” stated better way to predict heart disease:
Triglyceride (TG) and HDL ratio. Highest ratio , whopping 16x the risk of developing heart disease compare to lowest ratio, regardless of your cholesterol level.