The first symptom of heart disease can be dropped death. The processes toward heart disease is about 15 years before manifestations start to emerge. We have to take care the true cause of heart disease. Wrong approach will not yield good result. For example, reducing cholesterol by taking statin medicine only reduce end points (heart attack and death) by mere 0.4 – 3% in most studies and that happened in men, not in women. No significant difference in women taking statin had reduction in end points for heart disease compare to placebo in various studies but sadly many women are put on statin. What they are getting is just side effects.

The causative factor for heart disease is free radical and all of the above listed factors accelerate free radical namely oxidative stress. The most important causative factor that contribute to heart disease is inflammation and there are at least 20 factors contribute or accelerate inflammation. What we are concern here is chronic, low level and sub-clinical inflammation. Some factors may be tie-up into one such as sweet teeth (love to take sweet food or drink sweetened drinks) by itself can cause glucose spike beside will lead to hyperinsulinism. Hyperinsulinism leads to increase inflammation and increase fat synthesis and obesity. It also causes vicious cycle due to sugar craving of rebound hypoglycemia. The two factors is separated here to enable one to understand in different perspective.

We list here causative factors and associative factors to coronary heart disease. The list is not ranked according to major or minor importance. Major to some but not to others, therefore we just list it out here.

Causative factors and associative factors to coronary heart disease:

1. Family history

Family history is a non-modifiable factor, nevertheless it is one of the most significant factor. Few other associated factors have a strong familial connection that may occur at the same time, explain the significant of family history.

2. Increasing age

3. Male sex

More women died of cardiovascular disease than men each year than. Men died earlier by seven to ten years than women that leads to the false believe that cardiovascular disease is problem of men. Women do die later and the leading cause of death among women is also heart disease.

4. Mental Stress

5. Heavy Metal

6. Chronic Fungus infection in blood

7. Frequent infection

8. Air Pollution

Air pollution causes people in northern China to live an average of 5.5 years shorter than their southern counterparts. They also found the variation to be attributable to cardiorespiratory illness, and not to other causes of death.  What the researchers called “ambient particulate matter pollution” was the fourth-leading risk factor for deaths in China in 2010. Air pollution ranked seventh on the worldwide list of risk factors, contributing to 3.2 million deaths in 2010. Read more.

Observation study in Malaysia noted death rate increase during serious haze period in 1997-1998 and 2005-2006. Read also an abstract from latest study.

9. Smoking

10. Not enough intake of antioxidant

11. Sedentary lifestyle or lack of exercise

Exercise is a proven life extender. Thousands of clinical trials have documented the benefits of a regular exercise. Exercise can reduce your risk of major illnesses, such as heart disease, stroke, diabetes and cancer by up to 50% and lower your risk of early death by up to 30%. People with type 2 diabetes and obesity face an increased risk for heart disease. Now a preliminary study suggests that regular exercise—even without a change in diet—might be a big help. Read more.

12. Obesity.

Obesity related to metabolic syndrome, insensitive to insulin, hypertension and statistically increase risk of cardiovascular disease. In a huge study showed that Body Mass Index (BMI) is a better predictive value for cardiovascular disease  than cholesterol. Read more.

13. Low EPA/DHA and High Omega 6/Omega 3 ratio

14. Inflammation

Elevated C-Reactive Protein(CRP) – CRP is an inflammatory marker

15. Excess insulin/Hyperinsulinism

16. Diabetic

Uncountable research proved lack of control of blood sugar associated with shorter life span by four years. Studies showed variable between four and as much as ten years. Diabetics usually die of heart disease, stroke, cancer or kidney failure complications. Read more.

17. Sweet teeth

18. Low HDL

19. Nitric oxide deficit

The finding on nitric oxide role in cardiovascular disease was awarded Nobel Prize in medicine in 1997.

20. Insufficient vitamin D

Emerging science argues strongly in favor of vitamin D as an important risk factor for cardiovascular disease. Optimizing vitamin D status holds tremendous potential to safely, inexpensively, and dramatically reduce cardiovascular risk. Replenishing vitamin D can help normalize blood pressure, support healthy blood sugar, improve insulin resistance, and dampen inflammation—all processes that contribute to heart disease.  Read more.

“….researchers at Harvard just announced that the five year survival for patients with early stage, non-small cell carcinoma of the lung was almost three times better in those with evidence of the highest vitamin D levels compared to those with the lowest. Five-year survival for those with the highest levels approached 80%! I predict similar claims will be filed against cardiologists for letting heart disease patients die vitamin D-deficient as the evidence mounts that vitamin D prevents and treats heart disease.”

—Dr. John Cannell The Vitamin D Council

21. Oxidized LDL

22. Excess cholesterol

Excess cholesterol especially the subtype  of high apolipoprotein B and low apolipoprotein A-I or simply apo B/A-I ratio. Many years of study showed more and more evidence of high apo B/A-I ratio instead of the commonly tested lipid profile or cholesterol that we used to understand. The apo B/A-I Ratio — A Stronger Predictor of Cardiovascular Events Than LDL, HDL, or Total Cholesterol, Triglycerides, or Lipid Ratios.

23. Hypertension.

Don’t ignore high blood pressure, it can be deadly. A target blood pressure of 115/75 mmHg yields the best preventative benefits. Read more.

24. Excess homocysteine

25. Excess fibrinogen

People with high levels of fibrinogen are more than twice as likely to die of a heart attack or stroke as people with normal fibrinogen levels. Read more.

26. Low free testosterone

27. Excess Triglyceride

A study by Harvard University, published in Journal “Circulation” stated better way to predict heart disease: Triglyceride (TG) and HDL ratio. Highest ratio , whopping 16x the risk of developing heart disease compare to lowest ratio, regardless of your cholesterol level. Read some more.

28. Excess oestrogen

29. Low vitamin K

30. Glucose spike after food

Glucose spike or surge after food even in non-diabetic is deadly.

31. Low magnesium or rather high calcium/magnesium ratio

32. Low DHEA hormone

33. High intake of trans-fatty acid.

In fact, there is no known safe limit for trans-fatty acid. Banned by law in many countries in Europe and USA. Some cities in USA have zero tolerance for public food consumption like in restaurant.

34. Excess Oestrogen

Here, we refer to oestrogen dominant. In women usually low progesterone to counteract the effect of oestrogen. Furthermore excess bad oestrogen can be in the form of xeno-oestrogen or oestrogen coming from outside of human body. They are chemicals that mimic oestrogen due to sharing of receptors to the chemicals. They are foreign to human body coming mostly from plasticizers and pesticide. There is the truth to “never heat food in plastic container and never wrapping hot food in plastic” in order to reduce xeno-oestrogen. Such bad oestrogen affecting men and women alike with various manifestation including ischemic heart disease. Read more on the mechanism.

Authors comment

The list is not arranged according to its importance. It is not right to arrange according to importance due to so wide variation in matters of important to some researchers but not to others. For example, cholesterol hypothesis is so important to some doctors but of minor issue to most doctors and irrelevant to some. What is the evidence that cholesterol hypothesis has poor basis?

We must therefore differentiate between causation and association, because by taking care of one or two associative factors usually do not protect one from heart disease. In other words, one may chop the wrong tree.

There are other interesting protective factors to heart disease such as:

Calorie restriction diet leads to better heart variability. Read more.

Promegranate juice protect heart. Read more.

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