Startling Findings About Vitamin D dose

References: Life Extension analysis on vitamin D level in 13,000 members

No other nutrient, drug, or hormone has gained more scientific credibility than vitamin D. Insufficient vitamin D is linked to virtually every age-related disorder including cancer, vascular disease, and chronic inflammation. Active vitamin D involves in about 3,000 gene expression.

Under Life extension test program more than 13,000 had their vitamin D level checked, the results from these tests represent a never-before-published data about achieved vitamin D blood levels in a large group of dedicated supplement users.

The findings will shock many in the medical community who think that supplementing with less than 1,000 IU a day of vitamin D is adequate. Minimal Vitamin D is not the same as optimal Vitamin D level. Most doctors prescribe only 250 IU, way too low for the intended benefit.

When irrefutable data emerged about vitamin D’s role in preventing disease, experts initially recommended a minimum target blood level of 30 ng/mL of 25-hydroxyvitamin D.

In recognition of findings showing reduced incidences of disease in those with higher vitamin D levels, the standard laboratory reference range for 25-hydroxyvitamin D was raised to 32-100 ng/mL.

Based on recent and conclusive published studies, Life Extension’s new minimum target level for optimal disease prevention is over 50 ng/mL of 25-hydroxyvitamin D.

85.7% of those tested have less than 50 ng/mL of 25-hydroxyvitamin D. While this may seem disconcerting, studies show that 50-78% of the general population has less than 30 ng/mL of 25-hydroxyvitamin D, placing them at high risk for a host of degenerative diseases.

The most disappointing finding was that 38% of test results for 25-hydroxyvitamin D were less than or equal to 30 ng/mL (the previous minimum threshold). In addition, 69% of test results were less than or equal to 40 ng/mL, and 85% of test results were less than or equal to 50 ng/mL.

New minimum target level for optimal disease prevention is 50 ng/mL of 25-hydroxyvitamin D

In fact, a startling 36%55-59 of the general population has 25-hydroxyvitamin D levels below 20 ng/mL, which may represent the world’s leading cause of unnecessary disease and death.

How Much Vitamin D Do You Need?1

John Cannell, MD, is the president of The Vitamin D Council, a non-profit group that advocates higher vitamin D intake. According to Dr. Cannell, adults need to take 5,000 IU a day of vitamin D to put the vast majority of them (97.5%) above the 50 ng/mL level.

To answer the question as to exactly how much vitamin D3 an individual needs requires a blood test.Dr. Cannell supplied published papers arguing that optimal doses for adults are between 4,600 and 10,000 IU, with persuasive evidence that 10,000 IU a day of supplemental vitamin D is not toxic.


Fears of vitamin D toxicity have caused health-conscious people to limit their vitamin D3 intake to only a 2few thousand IU (international units) a day. This amount is clearly inadequate to optimally protect against disease, based on recently published studies.